What Is Epigenomics

Epigenomics is the study of epigenetic modifications on the genetic material of a cell. The key difference between epigenomics and genomics is that epigenomics studies changes on the surface of DNA while genomics looks at changes within DNA. Epigenetic modifications are reversible modifications on a cell’s DNA or histones that affect gene expression without altering the DNA sequence. Such modifications affect regulation of gene activities, occurs independently of genomic changes, and cannot be detected by genomic means.

Two of the most characterized epigenetic modifications are DNA methylation and histone modification. Epigenetic modifications play an important role in gene expression and regulation and are involved in numerous cellular processes such as in differentiation, development, and tumorigenesis. While most epigenomic companies focus on DNA methylation, Auristone’s core technology centres around histone modifications.

Why use epigenomics?

Using Data to Improve Patient Outcomes

Genomic information is not sufficient

Current NGS tests only benefit < 50% of patients today as genomic aberrations only account for < 50% of cancers.

Poor predictive biomarkers for Immunotherapy

Immunotherapy has been available for > 10 years but approved biomarkers only identify 10-20% of responders.

Promising Epigenetic Targets

Paradigm shift to epigenomic driven therapies with the increase in number of clinical trials as promising targets for treatment of cancer.